| Primary Identifier | MGI:1856709 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Cftr |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| description | Epithelial tissue from the gastrointestinal tract and airways exhibit abnormal cyclic AMP-mediated chloride ion transport similar to that observed in CF patients (J:23817). |
| molecularNote | A neomycin selection cassette was inserted into exon 11 (exon 10 in legacy nomenclature numbering) at sequences corresponding to codon 489 of the encoded protein. The authors predict that a truncated protein with amino acid 488 changed from isoleucine to alanine and a stop codon at position 489 are produced from this allele. |
