| Primary Identifier | MGI:1857026 | Allele Type | Radiation induced |
| Gene | Foxq1 | Inheritance Mode | Recessive |
| Strain of Origin | (101/Rl x C3H/Rl)F1 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | This allele occurred in descendants of a gamma irradiation experiment. The underlying mutation was identified as a 67 bp intragenic deletion. The deletion causes a frame shift resulting in a truncated 376 amino acid protein but does not affect the first 228 residues, including the characteristic WH DNA-binding domain. The mutant protein is predicted to bind to its DNA targets but fails at transcriptional activation or repression because the specific C-terminal domains are missing. |
