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Publication : Restoration of staggerer mouse maternal behavior following long-term breeding selection.

First Author  Boufares S Year  1993
Journal  Physiol Behav Volume  53
Issue  6 Pages  1151-5
PubMed ID  8346298 Mgi Jnum  J:14497
Mgi Id  MGI:62664 Doi  10.1016/0031-9384(93)90372-m
Citation  Boufares S, et al. (1993) Restoration of staggerer mouse maternal behavior following long-term breeding selection. Physiol Behav 53(6):1151-5
abstractText  Two lines of staggerers from the C57BL/6 strain were tested for disturbances in maternal behavior and locomotion. One line, called Pasteur, included staggerers available at L'Institut Pasteur. The second line, called Selected, included staggerers that had been bred in our laboratory for several generations for their ability to reproduce. While none of the Pasteur animals showed any evidence of maternal behavior, most of the Selected mutant mice became maternal, carrying about 90% of the pups until weaning. No group differences were seen in locomotory behavior. It was concluded that a) as a result of long-term breeding selection, homozygous (sg/sg) animals of the C57BL/6 strain may be able to exhibit maternal behavior from birth on, even under standard laboratory conditions; b) the restoration of the maternal behavior does not equally affect all components of this behavior pattern; and c) the impairment of the maternal behavior showed by the staggerer females is not a necessary consequence of impaired locomotory capacity characteristic of the staggerer.
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