| First Author | Monaco ME | Year | 2004 |
| Journal | Biochem Biophys Res Commun | Volume | 317 |
| Issue | 2 | Pages | 444-50 |
| PubMed ID | 15063778 | Mgi Jnum | J:89178 |
| Mgi Id | MGI:3038595 | Doi | 10.1016/j.bbrc.2004.03.054 |
| Citation | Monaco ME, et al. (2004) Lipid metabolism in phosphatidylinositol transfer protein alpha-deficient vibrator mice. Biochem Biophys Res Commun 317(2):444-50 |
| abstractText | Mice that are homozygous for the vibrator mutation express 65-85% less phosphatidylinositol transfer protein alpha (PITPalpha) than their wild type litter mates. By postnatal day 10-12 (P10-12) they exhibit signs of neurodegeneration and die prematurely by P40. In the present study, we examine the lipid content of brain, liver, and mammary glands from these animals. Lipid-mediated signal transduction is evaluated in primary fibroblast cultures. With respect to the lipid make-up of brain and liver, we report that there is a significant increase (2- to 4-fold) in the neutral lipids present in the livers of vb/vb animals when compared with wild type (+/+) litter mates. No significant changes are observed in the brains of these animals. The mammary glands of vb/vb mice are underdeveloped with respect to ductal and alveolar structures, and the fat pad is composed of predominantly brown adipose tissue rather than the white adipose tissue characteristic of age-matched wild type litter mates. No differences are observed in any aspect of lipid-mediated signal transduction. |
