| First Author | Eaton GJ | Year | 1980 |
| Journal | Lab Anim | Volume | 14 |
| Issue | 1 | Pages | 17-24 |
| PubMed ID | 7359882 | Mgi Jnum | J:212823 |
| Mgi Id | MGI:5582282 | Doi | 10.1258/002367780780943141 |
| Citation | Eaton GJ, et al. (1980) The Icr:Ha(ICR) mouse: a current account of breeding, mutations, diseases and mortality. Lab Anim 14(1):17-24 |
| abstractText | This stock of albino mice is minimally inbred (0.5% per generation), and has been rigidly selected for fecundity. It is widely employed in oncological and pharmaceutical research. Spontaneous tumours arose in 55% of animals, multiple in 28%, averaging 1.66 per mouse. Females developed tumours at an earlier age than males. Predominant tumour types were pulmonary (23.1%), lymphoreticular (20%), and mammary (14%--23% of females). Miscellaneous tumour types (42.9%) ranged in frequency from 0.2 to 2.0%, the latter being hepatomas. Distribution of mammary tumours indicated that milk-borne mammary tumour virus was absent. Non-neoplastic disease was present in 58.6%, 24.1% being pulmonary and predominant in the young, while renal (31.2%) and cardiovascular (10.2%) disease was common in the elderly. Males outlived females. |
