| First Author | Schwartzberg PL | Year | 1989 |
| Journal | Science | Volume | 246 |
| Issue | 4931 | Pages | 799-803 |
| PubMed ID | 2554496 | Mgi Jnum | J:72519 |
| Mgi Id | MGI:2153193 | Doi | 10.1126/science.2554496 |
| Citation | Schwartzberg PL, et al. (1989) Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells. Science 246(4931):799-803 |
| abstractText | A substitution mutation has been introduced into the c-abl locus of murine embryonic stem cells by homologous recombination between exogenously added DNA and the endogenous gene, and these cells have been used to generate chimeric mice. It is shown that the c-abl mutation was transmitted to progeny by several male chimeras. This work demonstrates the feasibility of germ-line transmission of a mutation introduced into a nonselectable autosomal gene by homologous recombination. |
