| First Author | Hayakawa JI | Year | 1990 |
| Journal | Mouse Genome | Volume | 86 |
| Pages | 261 | Mgi Jnum | J:14288 |
| Mgi Id | MGI:62459 | Citation | Hayakawa JI, et al. (1990) Inheritance of juvenile visceral steatosis (jvs) found in C3H-H-2o mice. Mouse Genome 86:261 |
| abstractText | Full text of Mouse Genome contribution: INHERITANCE OF JUVENILE VISCERAL STEATOSIS (jvs) FOUND IN C3H-H-2(O) MICE Jun-ichiro Hayakawa, Tsutomu Koizumi and Hiroko Nikaido Institute for Experimental Animals, Kanazawa University, School of Medicine, 13-1, Takara-machi, Kanazawa 920, JAPAN We have reported an infantile disease association with visceral steatosis found in C3H-H-2O strain,* a MHC congenic strain of C3H mice(1). The affected mice are identifiable within 3-4 days of age by their whitish livers, which can be seen through abdominal skin. Although most of the affected mice die by 5 weeks of age, growth retardation is not noticed during first two weeks after birth. Recently we found that a very few mice which are identified by above criterion as the affected can survive more than 20 weeks (about 2.5% of the affected). Surviving males are fertile though they appear ruffled and generally weak. Then we studied the transmission of the disease when the surviving mice crossed were to other inbred strains, C3H/HeSlc, C57BL/6CrSlc, and DBA/2CrSlc. No F1 hybrid mice from these crosses developed the disease, but some of F2 and of the progeny from cross between F1 and heterozygous carrier C3H-H-2O mice developed the disease. The incidence of the disease in the progeny from each cross is summarized in following table: Partner strains: C3H/He; crosses: F1xF1; affected/total: 5/27; x2: 0.6049. Partner strains: C57BL/6; crosses: F1xF1; affected/total: 61/231; x2: 0.3308. Partner strains: C57BL/6; crosses: F1xC3H-H-2O; affected/total: 13/65; x2: 0.8866. Partner strains: DBA/2; crosses: F1xC3H-H-2O; affected/total: 22/120; x2: 2.7863. x2: Deviation from the expected ratio (1 : 3) of a single gene inheritance. No sex difference in the incidence was found. This result supports the previous view that the disease is caused by a single autosomal recessive mutant which newly arose in our C3H-H-2O strain. We propose to give a gene symbol, jvs (juvenile visceral steatosis) to this mutant. The linkage studies with autosomal marker genes are in progress. Biochemical basis of the disease is being studied in collaboration with Department of Biochemistry (Professor T. Saheki), Kagoshima University School of Medicine. Information on the characteristics of biochemical disorder will be obtained from Prof. Saheki. References 1. Laboratory Animals 22:83-87, 1988. * Non-standard inbred strain symbol. Ed. |
