| First Author | Sweet HO | Year | 1988 |
| Journal | Mouse News Lett | Volume | 81 |
| Pages | 70 | Mgi Jnum | J:23861 |
| Mgi Id | MGI:72837 | Citation | Sweet HO, et al. (1988) Mesenchymal dysplasia (mes). Mouse News Lett 81:70 |
| abstractText | Full text of MNL contribution: c) Mesenchymal dysplasia (mes). This new recessive mutation arose in CBA/J in 1981 and is now maintained on the B6C3Fe-a/a hybrid background by ovarian transplant. Homozygotes are characterized by shortened face, wide set eyes, excessive skin folds, belly spot, short kinked tail, preaxial polydactyly and thick foot pads. Mineralization of tendons and multiple skeletal defects are seen in alizarin stained specimens. Homozygous females have never produced liveborn offspring. Testes do not descend in homozygous males. Mes has been mapped to Chr 13 using two point repulsion and coupling intercrosses with bg, mu, and pe. Data from three point repulsion and coupling intercrosses suggest the probable order is mu - mes - pe, although missing recombinant classes in each cross (me + pe/+ mes +, n=300, mu mes +/+ + pe, n=261, mu mes pe/+ + +, n=223) complicated interpretation. Manuscript in preparation. (Sweet and R.T. Bronson) |
