| First Author | Messer A | Year | 1992 |
| Journal | Genomics | Volume | 13 |
| Issue | 3 | Pages | 797-802 |
| PubMed ID | 1639406 | Mgi Jnum | J:1224 |
| Mgi Id | MGI:49756 | Doi | 10.1016/0888-7543(92)90155-l |
| Citation | Messer A, et al. (1992) Mapping of the motor neuron degeneration (Mnd) gene, a mouse model of amyotrophic lateral sclerosis (ALS). Genomics 13(3):797-802 |
| abstractText | The motor neuron degeneration mutation (Mnd) causes a late-onset, progressive degeneration of upper and lower motor neurons in mice. After establishing genetic and environmental conditions that distinguish the phenotypes of Mnd/Mnd from +/Mnd mice, Mnd was mapped to proximal Chr 8, using endogenous retroviruses as markers. The map location was confirmed with additional linked polymorphic markers. The outcross/intercross matings to the strain AKR/J, which were used to follow the segregation of the retroviral markers with respect to Mnd, also revealed the existence of a timing effect. Approximately one-fourth of the affected Mnd/Mnd F2 progeny showed accelerated disease. The Mnd mouse model should allow study of mechanisms affecting onset and progression of specific neuronal degeneration in both animal and human neurological disease. |
