| Primary Identifier | MGI:1856847 | Allele Type | Spontaneous |
| Gene | Mreg | Inheritance Mode | Semidominant |
| Strain of Origin | STOCK a Myo5a<d> Hephl1<cw> | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Genomic PCR and DNA sequencing analysis showed the mutation is a deletion that spans the region from 11.1-kb upstream of the initiator methionine to intron 2. Northern and RT-PCR analysis demonstrated that no wild-type transcript could be detected in the mutant animals. Western blot analysis of homozygous mutant melanocytes showed that it also is not expressed at the protein level. |
