| First Author | Whitmore SP | Year | 1986 |
| Journal | Mouse News Lett | Volume | 74 |
| Pages | 107 | Mgi Jnum | J:14085 |
| Mgi Id | MGI:62262 | Citation | Whitmore SP (1986) Fathead (fhd). Mouse News Lett 74:107 |
| abstractText | Full text of MNL contribution: Research News: In complementation crosses made at Duke University (Div. Immunol. colony) to produce mice homozygous for three null alleles, Pep-2 (spontaneous), Pep-3 and Pep-7 (ENU induced), a skull deformity mutant appeared in the 4th generation. Examination of the pedigree indicated that the mutation was carried by one of the Pep-7 null parents. The mutation is recessive and appears to be linked to nonagouti (Chr. 2). Both normal and affected mice of the cross have interfrontal bones. In affected mice the nasal and premaxillary bones are shortened and twisted laterally to the left, the orbits are abnormally shaped, and the junction between the frontals and parietals is misaligned. Occlusion of incisors and molars is abnormal, and in some mice there are holes in the nasals. Mutants are recognizable by 3 weeks of age, but skulls of immature animals have not been examined. Affected mice of both sexes breed poorly, but it is presently unclear whether lack of breeding performance results from thismutation or from the triple null Pep phenotype. We have not yet been able to separate the mutations into different stocks. We are calling this mutant fathead (fhd). (S. Whitmore) |
