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Publication : Bone resorption restored in osteopetrotic mice by transplants of normal bone marrow and spleen cells.

First Author  Walker DG Year  1975
Journal  Science Volume  190
Issue  4216 Pages  784-5
PubMed ID  1105786 Mgi Jnum  J:5598
Mgi Id  MGI:54075 Doi  10.1126/science.1105786
Citation  Walker DG (1975) Bone resorption restored in osteopetrotic mice by transplants of normal bone marrow and spleen cells. Science 190(4216):784-5
abstractText  Capacity to resorb bone and calcified cartilage was restored permanently in mice with inherited osteopetrosis by the intravenous administration of cell suspensions prepared from spleen and bone marrow of normal littermates. Beginning near active growth plates as early as 2 weeks after transplantation, replacement of the abnormal spongiosa continued until medullary cavitites were fully expanded.
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