| First Author | Ferguson JM | Year | 1973 |
| Journal | Mouse News Lett | Volume | 49 |
| Pages | 23 | Mgi Jnum | J:13626 |
| Mgi Id | MGI:61808 | Citation | Ferguson JM, et al. (1973) Stumpy. Mouse News Lett 49:23 |
| abstractText | Full text of MNL contribution: Research News: A recessive mutant, stumpy, has appeared in an experiment testing the mutagenicity of the steroids used in contraceptive pills. It most resembles achondroplasia (cn, no linkage), but brachymorphic (bm, chromosome 19) and stubby (stb, chromosome 2) are somewhat similar. Stumpy mice have shorter heads and bodies than normals, the long bones of the limbs are especially shortened. They are viable, and recognisable at birth or a few days afterwards. The females are usually fertile but are not good mothers, and the males are usually sterile, A male stumpy, proven fertile with a stumpy female, has failed to breed with heterozygous females. Stumpy appears to be a new mutant, since crosses (below) with stb, bm and cn have failed to prove identity; the symbol stm is proposed. +stm x +stb gave 23 normals; +stm x +bm gave 16 normals; stmstm x +stb gave 5 normals; + stm x bmbm gave 39 normals; +stm x +cn gave 58 normals. Intercrosses stm B A/+ b at x stm B A/+ b at show it to be unlinked with the agouti locus (chromosome 2), but possibly linked with the brown (chromosome 4): AA - +: 46; AA Ð stm: 12; Aat +: 43; Aat stm: 21; atat +: 27; atat stm: 13; B +: 87; B stm: 38; b +: 30; b stm: 8; Contingency X2 (1 d.f.) for b/stm data = 1.257 Linkage with brown is being further tested in coupling backcrosses. We would like to find homes this side of the Atlantic for all four mutants. (Ferguson and Wallace). |
