| First Author | Mudalagiriyappa S | Year | 2022 |
| Journal | Cell Rep | Volume | 41 |
| Issue | 4 | Pages | 111543 |
| PubMed ID | 36288707 | Mgi Jnum | J:335123 |
| Mgi Id | MGI:7380192 | Doi | 10.1016/j.celrep.2022.111543 |
| Citation | Mudalagiriyappa S, et al. (2022) GM-CSF(+) Tc17 cells are required to bolster vaccine immunity against lethal fungal pneumonia without causing overt pathology. Cell Rep 41(4):111543 |
| abstractText | GM-CSF co-expressing T17 cells instigate pathologic inflammation during autoimmune disorders, but their function in immunity to infections is unclear. Here, we demonstrate the role of GM-CSF(+)Tc17 cells for vaccine immunity against lethal fungal pneumonia and the cytokine requirements for their induction and memory homeostasis. Vaccine-induced GM-CSF(+) Tc17 cells are necessary to bolster pulmonary fungal immunity without inflating pathology. Although GM-CSF expressing Tc17 cells preferentially elevate during the memory phase, their phenotypic attributes strongly suggest they are more like Tc17 cells than IFNgamma-producing Tc1 cells. IL-1 and IL-23, but not GM-CSF, are necessary to elicit GM-CSF(+) Tc17 cells following vaccination. IL-23 is dispensable for memory Tc17 and GM-CSF(+) Tc17 cell maintenance, but recall responses of effector or memory Tc17 cells in the lung require it. Our study reveals the beneficial, nonpathological role of GM-CSF(+) Tc17 cells during fungal vaccine immunity. |
