| First Author | Perry JSA | Year | 2018 |
| Journal | Immunity | Volume | 48 |
| Issue | 5 | Pages | 923-936.e4 |
| PubMed ID | 29752065 | Mgi Jnum | J:272662 |
| Mgi Id | MGI:6284486 | Doi | 10.1016/j.immuni.2018.04.007 |
| Citation | Perry JSA, et al. (2018) Transfer of Cell-Surface Antigens by Scavenger Receptor CD36 Promotes Thymic Regulatory T Cell Receptor Repertoire Development and Allo-tolerance. Immunity 48(5):923-936.e4 |
| abstractText | The development of T cell tolerance in the thymus requires the presentation of host proteins by multiple antigen-presenting cell (APC) types. However, the importance of transferring host antigens from transcription factor AIRE-dependent medullary thymic epithelial cells (mTECs) to bone marrow (BM) APCs is unknown. We report that antigen was primarily transferred from mTECs to CD8alpha(+) dendritic cells (DCs) and showed that CD36, a scavenger receptor selectively expressed on CD8alpha(+) DCs, mediated the transfer of cell-surface, but not cytoplasmic, antigens. The absence of CD8alpha(+) DCs or CD36 altered thymic T cell selection, as evidenced by TCR repertoire analysis and the loss of allo-tolerance in murine allogeneic BM transplantation (allo-BMT) studies. Decreases in these DCs and CD36 expression in peripheral blood of human allo-BMT patients correlated with graft-versus-host disease. Our findings suggest that CD36 facilitates transfer of mTEC-derived cell-surface antigen on CD8alpha(+) DCs to promote tolerance to host antigens during homeostasis and allo-BMT. |
