| First Author | Pacholczyk R | Year | 2007 |
| Journal | Immunity | Volume | 27 |
| Issue | 3 | Pages | 493-504 |
| PubMed ID | 17869133 | Mgi Jnum | J:125322 |
| Mgi Id | MGI:3758164 | Doi | 10.1016/j.immuni.2007.07.019 |
| Citation | Pacholczyk R, et al. (2007) Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells. Immunity 27(3):493-504 |
| abstractText | The majority of regulatory Foxp3+CD4+ T cells naturally arises in the thymus. It has been proposed that T cell receptors (TCRs) on these cells recognize self-MHC class II-peptide complexes with high or higher affinity and that their specificities mirror specificities of autoreactive T cells. Here, we analyzed hundreds of TCRs derived from regulatory or nonregulatory T cells and found little evidence that the former population preferably recognizes self-antigens as agonists. Instead, these cells recognized foreign MHC-peptide complexes as often as nonregulatory T cells. Our results show that high-affinity, autoreactive TCRs are rare on all CD4+ T cells and suggest that selecting self-peptide is different from the peptide that activates the same regulatory T cells in the periphery. |
