| First Author | Wang W | Year | 2020 |
| Journal | Cell Rep | Volume | 32 |
| Issue | 3 | Pages | 107936 |
| PubMed ID | 32698011 | Mgi Jnum | J:299370 |
| Mgi Id | MGI:6492013 | Doi | 10.1016/j.celrep.2020.107936 |
| Citation | Wang W, et al. (2020) The Interaction between Lymphoid Tissue Inducer-Like Cells and T Cells in the Mesenteric Lymph Node Restrains Intestinal Humoral Immunity. Cell Rep 32(3):107936 |
| abstractText | Lymphoid tissue inducer (LTi)/LTi-like cells are critical for lymphoid organogenesis and regulation of adaptive immunity in various tissues. However, the maintenance and regulation mechanisms of LTi-like cells among different tissues are not clear yet. Here, we find that LTi-like cells from different tissues display heterogeneity. The maintenance of LTi-like cells in the mesenteric lymph node (mLN), but not the gut, requires RANKL signaling from CD4(+) T cells. LTi-like cells from the mLN, but not the gut, could in turn inhibit the development of T follicular helper cells and subsequent humoral responses during intestinal immunization in an ID2- and PD-L1-dependent manner. Together, our findings implicate that the interaction between LTi-like cells and T cells in the mLN could precisely control the intestinal mucosal adaptive immune response. |
