| First Author | Yee Mon KJ | Year | 2021 |
| Journal | Cell Rep | Volume | 37 |
| Issue | 6 | Pages | 109969 |
| PubMed ID | 34758312 | Mgi Jnum | J:324667 |
| Mgi Id | MGI:6881827 | Doi | 10.1016/j.celrep.2021.109969 |
| Citation | Yee Mon KJ, et al. (2021) MicroRNA-29 specifies age-related differences in the CD8+ T cell immune response. Cell Rep 37(6):109969 |
| abstractText | MicroRNAs (miRNAs) have emerged as critical regulators of cell fate in the CD8+ T cell response to infection. Although there are several examples of miRNAs acting on effector CD8+ T cells after infection, it is unclear whether differential expression of one or more miRNAs in the naive state is consequential in altering their long-term trajectory. To answer this question, we examine the role of miR-29 in neonatal and adult CD8+ T cells, which express different amounts of miR-29 only prior to infection and adopt profoundly different fates after immune challenge. We find that manipulation of miR-29 expression in the naive state is sufficient for age-adjusting the phenotype and function of CD8+ T cells, including their regulatory landscapes and long-term differentiation trajectories after infection. Thus, miR-29 acts as a developmental switch by controlling the balance between a rapid effector response in neonates and the generation of long-lived memory in adults. |
