| First Author | Lu YJ | Year | 2021 |
| Journal | Cell Rep | Volume | 36 |
| Issue | 11 | Pages | 109696 |
| PubMed ID | 34525366 | Mgi Jnum | J:324787 |
| Mgi Id | MGI:6876890 | Doi | 10.1016/j.celrep.2021.109696 |
| Citation | Lu YJ, et al. (2021) CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection. Cell Rep 36(11):109696 |
| abstractText | CD4 T cells are essential for immunity to tuberculosis because they produce cytokines, including interferon-gamma. Whether CD4 T cells act as "helper" cells to promote optimal CD8 T cell responses during Mycobacterium tuberculosis is unknown. Using two independent models, we show that CD4 T cell help enhances CD8 effector functions and prevents CD8 T cell exhaustion. We demonstrate synergy between CD4 and CD8 T cells in promoting the survival of infected mice. Purified helped, but not helpless, CD8 T cells efficiently restrict intracellular bacterial growth in vitro. Thus, CD4 T cell help plays an essential role in generating protective CD8 T cell responses against M. tuberculosis infection in vitro and in vivo. We infer vaccines that elicit both CD4 and CD8 T cells are more likely to be successful than vaccines that elicit only CD4 or CD8 T cells. |
