| First Author | Mombaerts P | Year | 1995 |
| Journal | Int Rev Immunol | Volume | 13 |
| Issue | 1 | Pages | 43-63 |
| PubMed ID | 7494108 | Mgi Jnum | J:31055 |
| Mgi Id | MGI:78516 | Doi | 10.3109/08830189509061737 |
| Citation | Mombaerts P (1995) Lymphocyte development and function in T-cell receptor and RAG-1 mutant mice. Int Rev Immunol 13(1):43-63 |
| abstractText | We have used gene targeting in embryonic stem cells to generate mice with mutations in T-cell receptor (TCR) gene-alpha, TCR-beta, TCR-delta or the Recombination Activating Gene-1 (RAG-1). TCR-alpha or TCR-beta mutant mice are deficient in alpha beta T cells, but still contain gamma delta T cells and B cells. TCR-delta mutant mice are deficient in gamma delta T cells, but still contain alpha beta T cells and B cells. Mice doubly mutant for TCR-beta and TCR-delta do not have any mature T cells, but still have B cells. RAG-1 mutant mice are totally deficient in both mature T cells and B cells. Here, I describe recent studies of thymocyte development in the mutant mice, and I review experiments addressing the function of the immune system of the mutant mice. |
