| First Author | Harrison OJ | Year | 2019 |
| Journal | Science | Volume | 363 |
| Issue | 6422 | PubMed ID | 30523076 |
| Mgi Jnum | J:271547 | Mgi Id | MGI:6280571 |
| Doi | 10.1126/science.aat6280 | Citation | Harrison OJ, et al. (2019) Commensal-specific T cell plasticity promotes rapid tissue adaptation to injury. Science 363(6422) |
| abstractText | Barrier tissues are primary targets of environmental stressors and are home to the largest number of antigen-experienced lymphocytes in the body, including commensal-specific T cells. We found that skin-resident commensal-specific T cells harbor a paradoxical program characterized by a type 17 program associated with a poised type 2 state. Thus, in the context of injury and exposure to inflammatory mediators such as interleukin-18, these cells rapidly release type 2 cytokines, thereby acquiring contextual functions. Such acquisition of a type 2 effector program promotes tissue repair. Aberrant type 2 responses can also be unleashed in the context of local defects in immunoregulation. Thus, commensal-specific T cells co-opt tissue residency and cell-intrinsic flexibility as a means to promote both local immunity and tissue adaptation to injury. |
