| First Author | Haas JD | Year | 2012 |
| Journal | Immunity | Volume | 37 |
| Issue | 1 | Pages | 48-59 |
| PubMed ID | 22770884 | Mgi Jnum | J:187400 |
| Mgi Id | MGI:5436359 | Doi | 10.1016/j.immuni.2012.06.003 |
| Citation | Haas JD, et al. (2012) Development of interleukin-17-producing gammadelta T cells is restricted to a functional embryonic wave. Immunity 37(1):48-59 |
| abstractText | gammadelta T cells are an important innate source of interleukin-17 (IL-17). In contrast to T helper 17 (Th17) cell differentiation, which occurs in the periphery, IL-17-producing gammadelta T cells (gammadeltaT17 cells) are probably committed during thymic development. To study when gammadeltaT17 cells arise during ontogeny, we used TcrdH2BeGFP reporter mice to monitor T cell receptor (TCR) rearrangement and IL-17 production in the embryonic thymus. We observed that several populations such as innate lymphoid cells and early T cell precursors were able to produce IL-17 prior to (and thus independent of) TCR recombination. gammadeltaT17 cells were absent after transplantation of IL-17-sufficient bone marrow into mice lacking both Il17a and Il17f. Also, gammadeltaT17 cells were not generated after genetic restoration of defective Rag1 function in adult mice. Together, these data suggested that these cells developed exclusively before birth and subsequently persisted in adult mice as self-renewing, long-lived cells. |
