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Allele : Tcrb<tm1Mom> T cell receptor beta chain; targeted mutation 1, Peter Mombaerts

Primary Identifier	MGI:1857256	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Tcrb
Transmission	Germline	Strain of Origin	129P2/OlaHsd
Is Recombinase	false	Is Wild Type	false

molecularNote

15kb of sequence was replaced with a PGK-neo cassette. The deletion included one of the two D gene segments, ten of the twelve J gene segments, and both constant gene segments.

mutations:
Insertion,
Intragenic deletion

cellLines:
Not Specified

synonyms:
TCRb<->,
TCRb<->,
beta-,
CBeta<->,
CBeta<->,
TCR-Cbeta-,
TCRbeta-,
TCRbeta-,
TCR-Cbeta-,
beta-

earliestPublication:
Mombaerts P, et al. (1991) Creation of a large genomic deletion at the T-cell antigen receptor beta-subunit locus in mouse embryonic stem cells by gene targeting. Proc Natl Acad Sci U S A 88(8):3084-7

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

18 Carried By

0 Driven By

518 Publication categories

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