| First Author | Ferrero I | Year | 2006 |
| Journal | J Immunol | Volume | 177 |
| Issue | 9 | Pages | 6038-43 |
| PubMed ID | 17056529 | Mgi Jnum | J:140526 |
| Mgi Id | MGI:3814027 | Doi | 10.4049/jimmunol.177.9.6038 |
| Citation | Ferrero I, et al. (2006) TCRgamma silencing during alphabeta T cell development depends upon pre-TCR-induced proliferation. J Immunol 177(9):6038-43 |
| abstractText | During thymus development, immature T cells become committed to two distinct lineages based upon expression of alphabeta or gammadelta TCR. In the alphabeta lineage, developing thymocytes progressively extinguish transcription of the TCRgamma genes by a poorly understood process known as gamma silencing. We show that alphabeta lineage thymocytes in mice lacking a functional pre-TCR undergo limited proliferation and fail to silence TCRgamma genes during development. Stimulation of pre-TCR-deficient immature thymocytes with anti-CD3 Abs does not directly down-regulate TCRgamma transcription but restores TCRgamma silencing following proliferation. Collectively our data reveal an important role for pre-TCR induced proliferation in activating the TCRgamma silencer in alphabeta lineage thymocytes, a process that may reinforce alphabeta or gammadelta lineage commitment. |
