| First Author | Sun Y | Year | 2005 |
| Journal | J Immunol | Volume | 175 |
| Issue | 2 | Pages | 884-90 |
| PubMed ID | 16002686 | Mgi Jnum | J:100693 |
| Mgi Id | MGI:3589312 | Doi | 10.4049/jimmunol.175.2.884 |
| Citation | Sun Y, et al. (2005) Regulation of follicular dendritic cell networks by activated T cells: the role of CD137 signaling. J Immunol 175(2):884-90 |
| abstractText | B cells, but not T cells, are considered to be important for the formation of follicular dendritic cell (FDC) clusters. Stimulation with agonist mAbs against CD137 (4-1BB), a TNFR family member primarily expressed on activated T cells, was effective in promoting T cell responses, but paradoxically suppressed T-dependent humoral immunity and autoantibody production in autoimmune disease models. Our present study shows that agonistic anti-CD137 treatment activates T cells, resulting in diminished FDC networks in B cell follicles, which are important components in T-dependent humoral immune responses both before and after the initiation of an immune response. Pretreatment with anti-CD137 before the secondary immunization inhibited memory Ab responses. Interestingly, CD137 costimulation-induced diminishment of FDC is T cell dependent. In addition, both CD4(+) and CD8(+) T cells are recruited into FDC area and are able to regulate FDCs by CD137 costimulation through a direct or indirect mechanism. These studies have revealed a previously unappreciated role of T cells in the regulation of FDC networks. |
