| First Author | Jeannet G | Year | 2006 |
| Journal | Eur J Immunol | Volume | 36 |
| Issue | 10 | Pages | 2725-34 |
| PubMed ID | 16955521 | Mgi Jnum | J:118107 |
| Mgi Id | MGI:3698616 | Doi | 10.1002/eji.200636011 |
| Citation | Jeannet G, et al. (2006) T and B lymphocytes exert distinct effects on the homeostasis of NK cells. Eur J Immunol 36(10):2725-34 |
| abstractText | There is growing evidence that lymphocytes impact the development and/or function of other lymphocyte populations. Based on such observations we have tested whether the NK cell compartment was phenotypically and functionally altered in the absence of B and/or T cells. Here we show that T cell deficiency significantly accelerates BM NK cell production and the subsequent seeding of splenic and liver NK cell compartments. In contrast, B cell deficiency reduces splenic NK cell survival. In the absence of T and B cells, the size of the NK cell compartments is determined by the combination of these positive and negative effects. Even though NK cell homeostasis is significantly altered, NK cells from T and/or B cell-deficient mice show a normal capacity to kill a susceptible target cell line and to produce IFN. Nevertheless, we noted that the usage of MHC class I-specific Ly49 family receptors was significantly altered in the absence of T and/or B cells. In general, B cell deficiency expanded Ly49 receptor usage, while T cell deficiency exerted both positive and negative effects. These findings show that B and T cells significantly and differentially influence the homeostasis and the phenotype of NK cells. |
