| First Author | Obukhanych TV | Year | 2006 |
| Journal | J Exp Med | Volume | 203 |
| Issue | 2 | Pages | 305-10 |
| PubMed ID | 16476769 | Mgi Jnum | J:119148 |
| Mgi Id | MGI:3701377 | Doi | 10.1084/jem.20052036 |
| Citation | Obukhanych TV, et al. (2006) T-independent type II immune responses generate memory B cells. J Exp Med 203(2):305-10 |
| abstractText | Unlike T-dependent immune responses against protein antigens, T-independent responses against polysaccharides confer long-lasting humoral immunity in the absence of recall responses and are not known to generate memory B cells. Here we report that polysaccharide antigens elicit memory B cells that are phenotypically distinct from those elicited by protein antigens. Furthermore, memory B cell responses against polysaccharides are regulated by antigen-specific immunoglobulin G antibodies. As the generation and regulation of immunologic memory is central to vaccination, our findings help explain the mode of action of the few existing polysaccharide vaccines and provide a rationale for a wider application of polysaccharide-based strategies in vaccination. |
