| First Author | Cariappa A | Year | 2005 |
| Journal | Immunity | Volume | 23 |
| Issue | 4 | Pages | 397-407 |
| PubMed ID | 16226505 | Mgi Jnum | J:113277 |
| Mgi Id | MGI:3665345 | Doi | 10.1016/j.immuni.2005.09.004 |
| Citation | Cariappa A, et al. (2005) Perisinusoidal B cells in the bone marrow participate in T-independent responses to blood-borne microbes. Immunity 23(4):397-407 |
| abstractText | Mature recirculating B cells are generally assumed to exist in follicular niches in secondary lymphoid organs, and these cells mediate T-dependent humoral immune responses. We show here that a large proportion of mature B lymphocytes occupy an anatomically and functionally distinct perisinusoidal niche in the bone marrow. Perisinusoidal B cells circulate freely, as revealed by parabiosis studies. However, unlike their counterparts in the follicular niche, these cells are capable of being activated in situ by blood-borne microbes in a T-independent manner to generate specific IgM antibodies. The bone marrow represents a unique type of secondary lymphoid organ in which mature B cells are strategically positioned in the path of circulating microbes. |
