| First Author | Golovkina TV | Year | 1999 |
| Journal | Science | Volume | 286 |
| Issue | 5446 | Pages | 1965-8 |
| PubMed ID | 10583962 | Mgi Jnum | J:124532 |
| Mgi Id | MGI:3721832 | Doi | 10.1126/science.286.5446.1965 |
| Citation | Golovkina TV, et al. (1999) Organogenic role of B lymphocytes in mucosal immunity. Science 286(5446):1965-8 |
| abstractText | Follicle-associated epithelium (FAE) in the intestinal Peyer's patches contains M cells that deliver pathogens to organized lymphoid tissue. Development of Peyer's patches, FAE, and M cells was found to be impaired in mice that had no B cells. Transgenic expression of membrane-bound immunoglobulin M restored B cells and FAE development. The lack of M cells abrogated infection with a milk-borne retrovirus. Thus, in addition to secretion of antibodies and presentation of antigens, B cells are important for organogenesis of the mucosal immune barriers. |
