| First Author | Burrows K | Year | 2025 |
| Journal | Cell | Volume | 188 |
| Issue | 2 | Pages | 316-330.e12 |
| PubMed ID | 39706191 | Mgi Jnum | J:361348 |
| Mgi Id | MGI:7856350 | Doi | 10.1016/j.cell.2024.11.020 |
| Citation | Burrows K, et al. (2025) A gut commensal protozoan determines respiratory disease outcomes by shaping pulmonary immunity. Cell 188(2):316-330.e12 |
| abstractText | The underlying mechanisms used by the intestinal microbiota to shape disease outcomes of the host are poorly understood. Here, we show that the gut commensal protozoan, Tritrichomonas musculis (T.mu), remotely shapes the lung immune landscape to facilitate perivascular shielding of the airways by eosinophils. Lung-specific eosinophilia requires a tripartite immune network between gut-derived inflammatory group 2 innate lymphoid cells and lung-resident T cells and B cells. This network exacerbates the severity of allergic airway inflammation while hindering the systemic dissemination of pulmonary Mycobacterium tuberculosis. The identification of protozoan DNA sequences in the sputum of patients with severe allergic asthma further emphasizes the relevance of commensal protozoa in human disease. Collectively, these findings demonstrate that a commensal protozoan tunes pulmonary immunity via a gut-operated lung immune network, promoting both beneficial and detrimental disease outcomes in response to environmental airway allergens and pulmonary infections. |
