| First Author | Do J | Year | 2016 |
| Journal | Eur J Immunol | Volume | 46 |
| Issue | 2 | Pages | 340-6 |
| PubMed ID | 26549797 | Mgi Jnum | J:234524 |
| Mgi Id | MGI:5790160 | Doi | 10.1002/eji.201545919 |
| Citation | Do J, et al. (2016) gammadelta T cells support gut Ag-reactive colitogenic effector T-cell generation by enhancing Ag presentation by CD11b(+) DCs in the mesenteric LN. Eur J Immunol 46(2):340-6 |
| abstractText | T cells expressing the gammadelta TCR are dominant T-cell subsets in the intestinal immune system. We previously demonstrated that gammadelta T cells play important roles in augmenting Th17-type colitogenic immune responses in a T-cell-induced colitic inflammation model. However, its underlying mechanism remains poorly understood. In this study, an in vitro coculture system using effector T cells enriched in gut Ag-reactive cells was employed as a readout tool to search for gut Ag presenting APCs. We found that the presence of gammadelta T cells dramatically enhances gut Ag presentation within the mLN in mice. Gut Ag presentation by CD11b(+) DC subsets was particularly controlled by gammadelta T cells. Interestingly, gammadelta T-cell entry to the lymph nodes was essential to improve the Ag presentation. Therefore, our results highlight that gammadelta T cells play a previously unrecognized role to support colitogenic immunity by regulating gut Ag presentation in the draining LN. |
