| First Author | Schaeuble K | Year | 2017 |
| Journal | Cell Rep | Volume | 21 |
| Issue | 9 | Pages | 2500-2514 |
| PubMed ID | 29186687 | Mgi Jnum | J:255233 |
| Mgi Id | MGI:6103926 | Doi | 10.1016/j.celrep.2017.10.119 |
| Citation | Schaeuble K, et al. (2017) Perivascular Fibroblasts of the Developing Spleen Act as LTalpha1beta2-Dependent Precursors of Both T and B Zone Organizer Cells. Cell Rep 21(9):2500-2514 |
| abstractText | T and B cell compartmentalization is a hallmark of secondary lymphoid organs and is maintained by chemokine-expressing stromal cells. How this stromal cell network initially develops and differentiates into two distinct subsets is poorly known, especially for the splenic white pulp (WP). Here, we show that perivascular fibroblast precursors are triggered by LTalpha1beta2 signals to expand, express CCL19/21, and then differentiate into two functionally distinct fibroblast subsets responsible for B and T cell clustering and WP compartmentalization. Failure to express or sense CCL19 leads to impaired T zone development, while lack of B cells or LTalpha1beta2 leads to an earlier and stronger impairment in WP development. We therefore propose that WP development proceeds in multiple steps, with LTalpha1beta2(+) B cells acting as major inducer cells driving the expansion and gradual differentiation of perivascular fibroblasts into T and B zone organizer cells. |
