| First Author | Vieth JA | Year | 2017 |
| Journal | Nat Immunol | Volume | 18 |
| Issue | 1 | Pages | 36-44 |
| PubMed ID | 27869818 | Mgi Jnum | J:259384 |
| Mgi Id | MGI:6141323 | Doi | 10.1038/ni.3622 |
| Citation | Vieth JA, et al. (2017) TCRalpha-TCRbeta pairing controls recognition of CD1d and directs the development of adipose NKT cells. Nat Immunol 18(1):36-44 |
| abstractText | The interaction between the T cell antigen receptor (TCR) expressed by natural killer T cells (NKT cells) and the antigen-presenting molecule CD1d is distinct from interactions between the TCR and major histocompatibility complex (MHC). Our molecular modeling suggested that a hydrophobic patch created after TCRalpha-TCRbeta pairing has a role in maintaining the conformation of the NKT cell TCR. Disruption of this patch ablated recognition of CD1d by the NKT cell TCR but not interactions of the TCR with MHC. Partial disruption of the patch, while permissive to the recognition of CD1d, significantly altered NKT cell development, which resulted in the selective accumulation of adipose-tissue-resident NKT cells. These results indicate that a key component of the TCR is essential for the development of a distinct population of NKT cells. |
