| First Author | Kursar M | Year | 2005 |
| Journal | J Exp Med | Volume | 201 |
| Issue | 9 | Pages | 1447-57 |
| PubMed ID | 15851484 | Mgi Jnum | J:98197 |
| Mgi Id | MGI:3577594 | Doi | 10.1084/jem.20041204 |
| Citation | Kursar M, et al. (2005) Differential requirements for the chemokine receptor CCR7 in T cell activation during Listeria monocytogenes infection. J Exp Med 201(9):1447-57 |
| abstractText | Effective priming of T cell responses depends on cognate interactions between naive T cells and professional antigen-presenting cells (APCs). This contact is the result of highly coordinated migration processes, in which the chemokine receptor CCR7 and its ligands, CCL19 and CCL21, play a central role. We used the murine Listeria monocytogenes infection model to characterize the role of the CCR7/CCR7 ligand system in the generation of T cell responses during bacterial infection. We demonstrate that efficient priming of naive major histocompatibility complex (MHC) class Ia-restricted CD8(+) T cells requires CCR7. In contrast, MHC class Ib-restricted CD8(+) T cells and MHC class II-restricted CD4(+) T cells seem to be less dependent on CCR7; memory T cell responses are independent of CCR7. Infection experiments with bone marrow chimeras or mice reconstituted with purified T cell populations indicate that CCR7 has to be expressed on CD8(+) T cells and professional APCs to promote efficient MHC class Ia-restricted T cell priming. Thus, different T cell subtypes and maturation stages have discrete requirements for CCR7. |
