| First Author | Strid J | Year | 2011 |
| Journal | Science | Volume | 334 |
| Issue | 6060 | Pages | 1293-7 |
| PubMed ID | 22144628 | Mgi Jnum | J:178921 |
| Mgi Id | MGI:5300634 | Doi | 10.1126/science.1211250 |
| Citation | Strid J, et al. (2011) The intraepithelial T cell response to NKG2D-ligands links lymphoid stress surveillance to atopy. Science 334(6060):1293-7 |
| abstractText | Epithelial cells respond to physicochemical damage with up-regulation of major histocompatibility complex-like ligands that can activate the cytolytic potential of neighboring intraepithelial T cells by binding the activating receptor, NKG2D. The systemic implications of this lymphoid stress-surveillance response, however, are unknown. We found that antigens encountered at the same time as cutaneous epithelial stress induced strong primary and secondary systemic, T helper 2 (T(H)2)-associated atopic responses in mice. These responses required NKG2D-dependent communication between dysregulated epithelial cells and tissue-associated lymphoid cells. These data are germane to uncertainty over the afferent induction of T(H)2 responses and provide a molecular framework for considering atopy as an important component of the response to tissue damage and carcinogenesis. |
