| First Author | Lahn M | Year | 1999 |
| Journal | Nat Med | Volume | 5 |
| Issue | 10 | Pages | 1150-6 |
| PubMed ID | 10502818 | Mgi Jnum | J:124003 |
| Mgi Id | MGI:3720317 | Doi | 10.1038/13476 |
| Citation | Lahn M, et al. (1999) Negative regulation of airway responsiveness that is dependent on gammadelta T cells and independent of alphabeta T cells. Nat Med 5(10):1150-6 |
| abstractText | The mechanisms regulating airway function are complex and still poorly understood. In diseases such as asthma, involvement of immune-dependent mechanisms has been suggested in causing changes in airway responsiveness to bronchoconstrictors. We now demonstrate that gammadelta T cells can regulate airway function in an alphabeta T cell-independent manner, identifying them as important cells in pulmonary homeostasis. This function of gammadelta T cells differs from previously described immune-dependent mechanisms and may reflect their interaction with innate systems of host defense. |
