| First Author | Dubey LK | Year | 2019 |
| Journal | Cell Rep | Volume | 27 |
| Issue | 8 | Pages | 2442-2458.e5 |
| PubMed ID | 31116987 | Mgi Jnum | J:284427 |
| Mgi Id | MGI:6381157 | Doi | 10.1016/j.celrep.2019.04.079 |
| Citation | Dubey LK, et al. (2019) IL-4Ralpha-Expressing B Cells Are Required for CXCL13 Production by Fibroblastic Reticular Cells. Cell Rep 27(8):2442-2458.e5 |
| abstractText | Adaptive type 2 immune responses against the intestinal helminth Heligmosomoides polygyrus (Hp) require the interaction of follicle-associated CXCR5(+) dendritic cells with naive T cells in the draining mesenteric lymph nodes (mLNs). However, the source of CXCL13 responsible for attracting CXCR5(+) dendritic cells has remained unclear. Using multiplex imaging combined with deep tissue analysis, we observed new CXCL13(+) fibroblastic reticular cells surrounding paracortical and cortical B cell follicles in the mLNs of infected mice. CXCL13(+) fibroblasts expressed markers of marginal reticular cells (MRCs), and their expansion required lymphotoxin (LT)-dependent interactions between IL-4Ralpha-expressing B cells and CCL19(+) fibroblasts. Infection-induced follicles did not necessarily contain follicular dendritic cells (FDCs), indicating that CXCL13(+) fibroblasts may instead drive their formation. These data reveal a role for lymphotoxin signaling to CCL19(+) fibroblasts in the development of CXCL13(+) MRC-like cells and adaptive type 2 immunity in response to helminth infection. |
