| First Author | Hatano S | Year | 2017 |
| Journal | Cell Rep | Volume | 21 |
| Issue | 5 | Pages | 1191-1202 |
| PubMed ID | 29091759 | Mgi Jnum | J:254853 |
| Mgi Id | MGI:6104021 | Doi | 10.1016/j.celrep.2017.10.007 |
| Citation | Hatano S, et al. (2017) CD5(-)NK1.1(+) gammadelta T Cells that Develop in a Bcl11b-Independent Manner Participate in Early Protection against Infection. Cell Rep 21(5):1191-1202 |
| abstractText | We recently found that a unique subset of innate-like gammadelta T cells develops from the DN2a stage of the fetal thymus independently of the zinc-finger transcription factor B cell leukemia/lymphoma 11b (Bcl11b). Herein, we characterize these Bcl11b-independent gammadelta T cells in the periphery as CD5(-)NK1.1(+) and Granzyme B(+), and we show that they are capable of producing interferon (IFN)-gamma upon T cell receptor stimulation without Ca(2+) influx. In wild-type mice, these cells were sparse in lymphoid tissues but abundant in non-lymphoid tissues, such as the liver. Bcl11b-independent CD5(-)NK1.1(+) gammadelta T cells appeared and contributed to early protection before Bcl11b-dependent CD5(+)NK1.1(-) gammadelta T cells following Listeria monocytogenes infection, resembling their sequential appearance during development in the thymus. |
