| First Author | Aifantis I | Year | 2006 |
| Journal | J Exp Med | Volume | 203 |
| Issue | 6 | Pages | 1543-50 |
| PubMed ID | 16754716 | Mgi Jnum | J:124376 |
| Mgi Id | MGI:3721448 | Doi | 10.1084/jem.20051711 |
| Citation | Aifantis I, et al. (2006) The E delta enhancer controls the generation of CD4- CD8- alphabetaTCR-expressing T cells that can give rise to different lineages of alphabeta T cells. J Exp Med 203(6):1543-50 |
| abstractText | It is well established that the pre-T cell receptor for antigen (TCR) is responsible for efficient expansion and differentiation of thymocytes with productive TCRbeta rearrangements. However, Ptcra- as well as Tcra-targeting experiments have suggested that the early expression of Tcra in CD4- CD8- cells can partially rescue the development of alphabeta CD4+ CD8+ cells in Ptcra-deficient mice. In this study, we show that the TCR E delta but not E alpha enhancer function is required for the cell surface expression of alphabetaTCR on immature CD4- CD8- T cell precursors, which play a crucial role in promoting alphabeta T cell development in the absence of pre-TCR. Thus, alphabetaTCR expression by CD4- CD8- thymocytes not only represents a transgenic artifact but occurs under physiological conditions. |
