| First Author | Rahimpour A | Year | 2012 |
| Journal | J Invest Dermatol | Volume | 132 |
| Issue | 6 | Pages | 1656-64 |
| PubMed ID | 22358058 | Mgi Jnum | J:188759 |
| Mgi Id | MGI:5441699 | Doi | 10.1038/jid.2012.16 |
| Citation | Rahimpour A, et al. (2012) gammadelta T cells augment rejection of skin grafts by enhancing cross-priming of CD8 T cells to skin-derived antigen. J Invest Dermatol 132(6):1656-64 |
| abstractText | Gamma delta T cells (gammadelta T cells) possess innate-like properties and are proposed to bridge the gap between innate and adaptive immunity. In this study, we explored the role of gammadelta T cells in cutaneous immunity using a skin transplantation model. Following engraftment of skin expressing cell-associated model antigen (Ag) (ovalbumin) in epithelial keratinocytes, skin-resident gammadelta T cells enhanced graft rejection. Although the effector function of CD8 T cells was intact in the absence of gammadelta T cells, cross-priming of CD8 T cell to graft-derived Ag was impaired in the absence of gammadelta T cells. The reduced graft rejection and graft priming of gammadelta T-cell-deficient mice was evident in both acutely inflamed and well-healed grafting models. Furthermore, expression of the CD40 activation marker on migrating dendritic cells was lower in TCRdelta(-/-) mice compared with wild-type mice, regardless of the presence or absence of inflammation associated with grafting. These results indicate that gammadelta T cells enhance graft priming and consequently the likelihood of a successful immune outcome in the context of skin graft rejection, suggesting that gammadelta T cells may be an important component of immunity to epithelial cancers or infection. |
