| First Author | Inagaki-Ohara K | Year | 2011 |
| Journal | Immunology | Volume | 134 |
| Issue | 4 | Pages | 448-58 |
| PubMed ID | 22044210 | Mgi Jnum | J:178638 |
| Mgi Id | MGI:5299391 | Doi | 10.1111/j.1365-2567.2011.03503.x |
| Citation | Inagaki-Ohara K, et al. (2011) gammadelta T cells play a protective role during infection with Nippostrongylus brasiliensis by promoting goblet cell function in the small intestine. Immunology 134(4):448-58 |
| abstractText | The intestinal epithelium is rich in gammadelta T cells and the gut is a site of residence for a wide variety of pathogens, including nematodes. Although CD4+ T-cell receptor (TCR) -alphabeta+ T helper type 2 T cells are essential for the expulsion of intestinal nematodes, little information is available on the function of gammadelta T cells in this type of infection. Here, we demonstrate two major functions of gammadelta T cells as a potently protective T-cell population against Nippostrongylus brasiliensis infection using gammadelta T-cell-deficient (TCR-delta(-/-) ) mice. First, gammadelta T cells are required to initiate rapid expulsion of adult worms from the intestine and to limit egg production. Second, gammadelta T cells prevent the pathological intestinal damage associated with nematode infection, evident by increased clinical disease and more severe microscopic lesions in infected TCR-delta(-/-) mice. gammadelta T-cell deficiency led to delayed goblet cell hyperplasia in association with reduced expression of phosphorylated STAT6, MUC2, Trefoil factor-3 (TFF3) and T helper type 2 cytokines including interleukin-13 (IL-13). TCR-delta(-/-) mice also produced more interferon-gamma than wild-type mice. Within the intraepithelial lymphocyte compartment, gammadelta T cells produced IL-13. Adoptive transfer of gammadelta T cells or administration of recombinant IL-13 to TCR-delta(-/-) mice successfully reduced the egg production by N. brasiliensis. Collectively, these data provide strong evidence that gammadelta T cells play an important role in controlling infection with intestinal nematodes and limiting infection-induced pathology. |
