| First Author | Sharp LL | Year | 2005 |
| Journal | Nat Immunol | Volume | 6 |
| Issue | 1 | Pages | 73-9 |
| PubMed ID | 15592472 | Mgi Jnum | J:94872 |
| Mgi Id | MGI:3521630 | Doi | 10.1038/ni1152 |
| Citation | Sharp LL, et al. (2005) Dendritic epidermal T cells regulate skin homeostasis through local production of insulin-like growth factor 1. Nat Immunol 6(1):73-9 |
| abstractText | A fine balance between rates of proliferation and apoptosis in the skin provides a defensive barrier and a mechanism for tissue repair after damage. Vgamma3(+) dendritic epidermal T cells (DETCs) are primary modulators of skin immune responses. Here we show that DETCs both produce and respond to insulin-like growth factor 1 (IGF-1) after T cell receptor stimulation. Mice deficient in DETCs had a notable increase in epidermal apoptosis that was abrogated by the addition of DETCs or IGF-1. Furthermore, DETC-deficient mice had reduced IGF-1 receptor activation at wound sites. These findings indicate critical functions for DETC-mediated IGF-1 production in regulating skin homeostasis and repair. |
