| First Author | Rampoldi F | Year | 2022 |
| Journal | Cell Rep | Volume | 39 |
| Issue | 8 | Pages | 110854 |
| PubMed ID | 35613579 | Mgi Jnum | J:326403 |
| Mgi Id | MGI:7284672 | Doi | 10.1016/j.celrep.2022.110854 |
| Citation | Rampoldi F, et al. (2022) gammadelta T cells license immature B cells to produce a broad range of polyreactive antibodies. Cell Rep 39(8):110854 |
| abstractText | Immature autoreactive B cells are present in all healthy individuals, but it is unclear which signals are required for their maturation into antibody-producing cells. Inducible depletion of gammadelta T cells show that direct interaction between gammadelta T cells and immature B cells in the spleen support an "innate" transition to mature B cells with a broad range of antigen specificities. IL-4 production of gammadelta T cells and cell-to-cell contact via CD30L support B cell maturation and induce genes of the unfolded protein response and mTORC1 signaling. Eight days after in vivo depletion of gammadelta T cells, increased numbers of B cells are already stuck in the transitional phase and express increased levels of IgD and CD21. Absence of gammadelta T cells leads also to reduced levels of serum anti-nuclear autoantibodies, making gammadelta T cells an attractive target to treat autoimmunity. |
