| First Author | Huber SA | Year | 2010 |
| Journal | Immunology | Volume | 131 |
| Issue | 2 | Pages | 202-9 |
| PubMed ID | 21050191 | Mgi Jnum | J:166680 |
| Mgi Id | MGI:4849310 | Doi | 10.1111/j.1365-2567.2010.03292.x |
| Citation | Huber SA (2010) gammadelta T lymphocytes kill T regulatory cells through CD1d. Immunology 131(2):202-9 |
| abstractText | Coxsackievirus B3 (CVB3) induces myocarditis, an inflammation of the myocardium, in C57Bl/6 male mice but not in mice lacking gammadelta+ T cells [gammadelta knockout (gammadeltaKO)]. Suppression of myocarditis in gammadeltaKO mice corresponds to an increase in CD4(+) CD25(+) FoxP3(+) T regulatory cells. A subpopulation of the T regulatory cells in infected gammadeltaKO mice expressed high levels of CD1d, a non-classical major histocompatibility complex class 1-like molecule. Adoptive transfer of CD1d(+) and CD1d(-) CD4(+) CD25(+) cells into infected C57Bl/6 recipients showed that the CD1d(+) subpopulation is substantially more suppressive than the CD1d(-) subpopulation. T cells expressing the gammadelta T-cell receptor comprised approximately 30-50% of the infiltrating lymphoid cells in the hearts of myocarditic C57Bl/6 mice and approximately half of the gammadelta+ cells expressed the Vgamma4 T-cell receptor. The Vgamma4+ cells lysed T regulatory cells from gammadeltaKO mice but not from wild-type (C57Bl/6) animals. Lysis was inhibited by antibody to CD1d and zVAD-fmk, a pan-caspase inhibitor. The Vgamma4-gammadelta+ cells were not lytic to T regulatory cells and did not promote myocarditis. These results demonstrate that Vgamma4+ cells selectively abrogate T regulatory cells through recognition of CD1d expressed on the regulatory cells and caspase-dependent apoptosis. |
