| First Author | Lockhart E | Year | 2006 |
| Journal | J Immunol | Volume | 177 |
| Issue | 7 | Pages | 4662-9 |
| PubMed ID | 16982905 | Mgi Jnum | J:139315 |
| Mgi Id | MGI:3807740 | Doi | 10.4049/jimmunol.177.7.4662 |
| Citation | Lockhart E, et al. (2006) IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection. J Immunol 177(7):4662-9 |
| abstractText | IL-17 is a cytokine produced by T cells in response to IL-23. Recent data support a new subset of CD4 Th cells distinct from Th1 or Th2 cells that produce IL-17 and may contribute to inflammation. In this study, we demonstrate that, in naive mice, as well as during Mycobacterium tuberculosis infection, IL-17 production is primarily from gammadelta T cells and other non-CD4(+)CD8(+) cells, rather than CD4 T cells. The production of IL-17 by these cells is stimulated by IL-23 alone, and strongly induced by the cytokines, including IL-23, produced by M. tuberculosis-infected dendritic cells. IL-23 is present in the lungs early in infection and the IL-17-producing cells, such as gammadelta T cells, may represent a central innate protective response to pulmonary infection. |
