| First Author | Shull MM | Year | 1992 |
| Journal | Nature | Volume | 359 |
| Issue | 6397 | Pages | 693-9 |
| PubMed ID | 1436033 | Mgi Jnum | J:2892 |
| Mgi Id | MGI:51412 | Doi | 10.1038/359693a0 |
| Citation | Shull MM, et al. (1992) Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 359(6397):693-9 |
| abstractText | Transforming growth factor-beta 1 (TGF-beta 1) is a multifunctional growth factor that has profound regulatory effects on many developmental and physiological processes. Disruption of the TGF-beta 1 gene by homologous recombination in murine embryonic stem cells enables mice to be generated that carry the disrupted allele. Animals homozygous for the mutated TGF-beta 1 allele show no gross developmental abnormalities, but about 20 days after birth they succumb to a wasting syndrome accompanied by a multifocal, mixed inflammatory cell response and tissue necrosis, leading to organ failure and death. TGF-beta 1-deficient mice may be valuable models for human immune and inflammatory disorders, including autoimmune diseases, transplant rejection and graft versus host reactions. |
