| First Author | Unterholzner L | Year | 2010 |
| Journal | Nat Immunol | Volume | 11 |
| Issue | 11 | Pages | 997-1004 |
| PubMed ID | 20890285 | Mgi Jnum | J:166541 |
| Mgi Id | MGI:4847995 | Doi | 10.1038/ni.1932 |
| Citation | Unterholzner L, et al. (2010) IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol 11(11):997-1004 |
| abstractText | The detection of intracellular microbial DNA is critical to appropriate innate immune responses; however, knowledge of how such DNA is sensed is limited. Here we identify IFI16, a PYHIN protein, as an intracellular DNA sensor that mediates the induction of interferon-beta (IFN-beta). IFI16 directly associated with IFN-beta-inducing viral DNA motifs. STING, a critical mediator of IFN-beta responses to DNA, was recruited to IFI16 after DNA stimulation. Lowering the expression of IFI16 or its mouse ortholog p204 by RNA-mediated interference inhibited gene induction and activation of the transcription factors IRF3 and NF-kappaB induced by DNA and herpes simplex virus type 1 (HSV-1). IFI16 (p204) is the first PYHIN protein to our knowledge shown to be involved in IFN-beta induction. Thus, the PYHIN proteins IFI16 and AIM2 form a new family of innate DNA sensors we call 'AIM2-like receptors' (ALRs). |
