| First Author | Grell M | Year | 1998 |
| Journal | Eur J Immunol | Volume | 28 |
| Issue | 1 | Pages | 257-63 |
| PubMed ID | 9485205 | Mgi Jnum | J:45904 |
| Mgi Id | MGI:1196685 | Doi | 10.1002/(SICI)1521-4141(199801)28:01<257::AID-IMMU257>3.0.CO;2-G |
| Citation | Grell M, et al. (1998) TNF receptor type 2 mediates thymocyte proliferation independently of TNF receptor type 1. Eur J Immunol 28(1):257-63 |
| abstractText | Tumor necrosis factor (TNF) mediates its biological effects by binding to two distinct but homologous receptor molecules. The type 1 receptor (TNF-R1) has been shown to be essential and sufficient for most cellular responses to soluble TNF. In contrast, only limited data exist concerning the role of the type 2 receptor (TNF-R2) in TNF responses, both in vitro and in vivo. Here, we demonstrate by the use of thymocytes from TNF-R-deficient mice that the TNF-R2-dependent enhancement of proliferation and secretion of granulocyte-macrophage colony-stimulating factor is in fact mediated by TNF-R2 on its own, independent of co-expression and/or stimulation of TNF-R1. |
