| First Author | Napoli M | Year | 2016 |
| Journal | Cancer Cell | Volume | 29 |
| Issue | 6 | Pages | 874-888 |
| PubMed ID | 27300436 | Mgi Jnum | J:232328 |
| Mgi Id | MGI:5776624 | Doi | 10.1016/j.ccell.2016.04.016 |
| Citation | Napoli M, et al. (2016) DeltaNp63/DGCR8-Dependent MicroRNAs Mediate Therapeutic Efficacy of HDAC Inhibitors in Cancer. Cancer Cell 29(6):874-88 |
| abstractText | DeltaNp63 is an oncogenic member of the p53 family and acts to inhibit the tumor-suppressive activities of the p53 family. By performing a chemical library screen, we identified histone deacetylase inhibitors (HDACi) as agents reducing DeltaNp63 protein stability through the E3 ubiquitin ligase, Fbw7. DeltaNp63 inhibition decreases the levels of its transcriptional target, DGCR8, and the maturation of let-7d and miR-128, which we found to be critical for HDACi function in vitro and in vivo. Our work identified Fbw7 as a predictive marker for HDACi response in squamous cell carcinomas and lymphomas, and unveiled let-7d and miR-128 as specific targets to bypass tumor resistance to HDACi treatment. |
