| First Author | Slatter TL | Year | 2010 |
| Journal | Cell Death Differ | Volume | 17 |
| Issue | 3 | Pages | 540-50 |
| PubMed ID | 19779492 | Mgi Jnum | J:169434 |
| Mgi Id | MGI:4940966 | Doi | 10.1038/cdd.2009.136 |
| Citation | Slatter TL, et al. (2010) p53-mediated apoptosis prevents the accumulation of progenitor B cells and B-cell tumors. Cell Death Differ 17(3):540-50 |
| abstractText | We propose that the apoptotic function of p53 has an important role in B-cell homeostasis, which is important for the prevention of B-cell lymphomas. We created a mouse model (mDeltapro) that lacked residues 58-88 of the proline-rich domain of p53. mDeltapro is defective for apoptosis, but is able to arrest cell-cycle progression in hematopoietic tissues. mDeltapro develops late-onset B-cell lymphoma, but not the thymic T-cell tumors found in p53-null mice. Interestingly, mDeltapro lymphomas comprised incorrectly differentiated B cells. B-cell irregularities were also detected in mDeltapro before tumor onset, in which aged mice showed an increased population of inappropriately differentiated B cells in the bone marrow and spleen. We predict that by keeping B-cell populations in check, p53-dependent apoptosis prevents irregular B cells from eventuating in lymphomas. |
